Should I be able to play an mkv file on Infuse Pro 5 on Apple TV?

It plays using Infuse Pro 4 and 5 in iOS on an iPad, but nothing happens when I click on it in Apple TV in either version of Infuse.

it should not make any difference whether you are on iOS or tvOS as exactly the same files should play so I am not sure why you are having a problem. I guess you may need to raise a ticket with FireCore to see if they can help identify why you have a problem.